WASP: allele-specific software for robust molecular quantitative trait locus discovery

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WASP: allele-specific software for robust discovery of molecular quantitative trait loci

Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach h...

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ژورنال

عنوان ژورنال: Nature Methods

سال: 2015

ISSN: 1548-7091,1548-7105

DOI: 10.1038/nmeth.3582